To investigate the clinical relevance of UBE2NL and HIST2H3PS2 expression in ovarian cancer progression, we examined their mRNA expression levels in tissue samples obtained from patients at Cathay General Hospital (CGH), including benign ovarian cysts (n = 10), early-stage ovarian cancer (n = 21), and advanced-stage ovarian cancer (n = 35). This evidence concerns the gene UBE2NL and ovarian cancer.