LAMB2 and neoplasm: These in vitro angiogenesis models aim to examine the ability of EC to migrate and differentiate into capillary-like structures by cultivating EC in 3D-gels of extracellular matrix proteins like collagen, fibrin, Geltrex or Matrigel (two extracellular matrix-based hydrogels with laminin as major component) [27,28] or in co-culture models of EC with supporting cells, e.g., fibroblasts, mesenchymal stem cells, or tumor cells [27,29,30,31].