Several studies have repeatedly shown that Cx43 promotes angiogenesis e.g., in diabetic retinopathy [34], in pulmonary microvascular endothelial cells [35], or during reparative angiogenesis under chronic cerebral hypoperfusion [36], whereas Cx43 silencing inhibits this [14,15,16,36,37,38]. This evidence concerns the gene GJA1 and diabetic retinopathy.