HOTAIR and cancer: LncRNAs such as p50-Associated COX-2 Extragenic RNA (PACER), Highly Upregulated in Liver Cancer (HULC), HOTAIR, and MAF transcription factor G antisense RNA 1 (MAFG-AS1) are involved in regulating the expression of COX2 in various cancers, influencing immune suppression within the TME [108,109].