Li et al. (2017) reported the existence of a relationship between HMGB1 and the Tumor Protein P73 Antisense RNA 1 (TP73-AS1) in hepatocellular carcinoma (HCC), which is required to stimulate the expression of HMGB1 and NF-κB pathway-regulated cytokines [97]. The gene discussed is HMGB1; the disease is hepatocellular carcinoma.