ER stress-induced activation of PERK upregulates lncRNAs such as Golgin A2 pseudogene 10 (GOLGA2P10), which modulates Bcl-2 protein levels to protect hepatocellular carcinoma cells from apoptosis [67], and MALAT1, which enhances colorectal cancer cell migration following exposure to thapsigargin [68]. The gene discussed is MALAT1; the disease is colorectal cancer.