FOXO3 and ovarian cancer: Additionally, research on ovarian cancer stem cells in mice has shown that BPA administration induces ROS production, which decreases the expression of the antioxidant genes Superoxide dismuatase 1 (SOD1), Superoxide dismuatase 2 (SOD2), Catalase (CAT), Glutathion peroxidase (GPX1), and Forkhead box O3 (FOXO3), leading to BPA-induced oxidative stress [69].