Alongside this, MDK was associated with the expression of markers of immunosuppression including arginase-1 (Arg1), transforming growth factor beta (TGF-β), inducible nitric oxide synthase (NOS2), and interleukin 10, demonstrating that MDK is involved in facilitating a cancer-promoting tumor microenvironment [103]. This evidence concerns the gene ARG1 and neoplasm.