Nevertheless, a recent study supports a possible role for MDK in obesity-driven cancers, as MDK was identified as an upstream regulator involved in the gene expression changes and DNA damage accumulation seen in breast tissues in obese (BMI > 25) and non-obese (BMI 20–25) women with BRCA1 and BRCA2 mutations [82]. Here, MDK is linked to obesity due to melanocortin 4 receptor deficiency.