As the HIF-1α binding site in MDK’s promoter would suggest, hypoxia promotes MDK expression in the lungs [27] of mice as well as human PMNs [89], monocytes [89], HUVECs [89], glioblastoma [102], hepatocellular carcinoma [103], and non-small-cell lung cancer [93]. The gene discussed is MDK; the disease is hepatocellular carcinoma.