CASP3 and Parkinson disease: Part of the protective effect of IP6 against neurodegeneration may be attributed to its ability to (i) reduce ROS in peripheral neuropathy [56]; (ii) attenuate inflammatory responses in Parkinson’s disease mouse models [52]; (iii) reduce apoptosis by stimulating autophagy [2,48] and decreasing caspase-3 activity [51]; and (iv) restore mitochondrial membrane potential, a critical factor for neuronal survival [56].