vitamin D supplementation has been shown to reduce disease activity measured by systemic lupus erythematosus disease activity index (SLEDAI), systemic lupus erythematosus disease activity index 2000 (SLEDAI-2K), European Consensus Lupus Activity Measurement Index (ECLAM), fatigue by fatigue severity scale (K-FSS), inflammatory markers (e.g., IL-6), flare frequency, and steroid/immunosuppressant use, although the results are not uniform [111,163,164,165,166,167,168]. The gene discussed is IL6; the disease is systemic lupus erythematosus.