The type 2-shape of MRE11 kinetics generally reflects impaired or absent MRE11 foci as observed in syndromes caused by a mutated helicase (Bloom’s syndrome or Werner syndrome) or those caused by mutated protein upstream MRE11 function like ataxia telangiectasia or Nijmegen syndrome [45]. Here, MRE11 is linked to Ataxia-telangiectasia.