In terms of decompensated cirrhosis, a compilation of case reports outlined in reviews have also shown that SGLT2Is have a role in patients with refractory ascites in cirrhosis of various etiologies through their diuretic effect when used synergistically with loop diuretics and mineralocorticoid receptor antagonists which are the standard of care diuretics (SoCD) for cirrhosis related ascites [16,17,18,19,20,21]. The gene discussed is NR3C2; the disease is Ascites.