APP and early-onset autosomal dominant Alzheimer disease: Using an animal model of Alzheimer’s disease, with triple-transgenic mice (3 × Tg-AD) (harboring PS1 (M146V), APP (Swe), and tau (P301L) transgenes), it was demonstrated that the level of inflammatory cytokines (TNF-α, IL-1β, IL-6, NO) and COX-2 and iNOS protein expression were significantly higher in 3 × Tg-AD mice compared with WT control mice.