Luteolin reduced the expression of ER stress-related proteins such as GRP78 (78 kDa glucose-regulated protein or heat shock 70 kDa protein 5 (HSPA5, BIP)) and IRE1α (the serine/threonine protein kinase/endoribonuclease inositol-requiring enzyme 1-α) and the expression and co-localization of glial fibrillary acidic proteins (GFAPs) in AD animals and C6 cell models. The gene discussed is HSPA5; the disease is Alzheimer disease.