The modulation of Nrf2 pathways might be an effective approach for reducing Aβ and tau hyperactivation; thus, it was confirmed that quercetin, through the modulation of Nrf2 as well as due to its anti-oxidative properties, plays an important role in protection against Alzheimer’s disease [59]. The gene discussed is NFE2L2; the disease is early-onset autosomal dominant Alzheimer disease.