RB1 and central nervous system cancer: It is worth noting that studies such as those by Bachoo et al. (2002) showed that NSC and astrocytic transformation via deletion of the Ink4a/Arf locus (that encodes Retinoblastoma (RB) and p53), and epidermal growth factor receptor (EGFR) overexpression yielded tumours phenotypically similar to high-grade gliomas in vivo [162].