It is worth noting that studies such as those by Bachoo et al. (2002) showed that NSC and astrocytic transformation via deletion of the Ink4a/Arf locus (that encodes Retinoblastoma (RB) and p53), and epidermal growth factor receptor (EGFR) overexpression yielded tumours phenotypically similar to high-grade gliomas in vivo [162]. The gene discussed is CDKN2A; the disease is central nervous system cancer.