Further molecular profiling of 1122 diffuse glioma samples by Ceccarelli and colleagues in 2016 revealed IGFBP-2 protein elevation in glioblastoma with EGFR, P-EGFR and P-Akt, when compared with lower-grade gliomas (2016 CNS WHO grades II and III) [211]. Here, IGFBP2 is linked to central nervous system cancer.