IGFBP2 and glioblastoma: Furthermore, an assessment of IGFBP expression levels across 19 different cancer types deposited by The Cancer Genome Atlas in 2023 found that IGFBP2 mRNA levels were significantly associated with the prognosis of low-grade glioma (LGG) and glioblastoma (p-values: 8.3 × 10−33 and 1.2 × 10−3, respectively) (hazard ratios (95% confidence interval): 1.55 (1.44,1.68) and 1.24 (1.08, 1.40), respectively) [215].