ISH or IHC of astrocytoma and glioblastoma tissue has detected the IGF1R, IGF1 and IGF2, although overall IGF2 seems much less prevalent (5/88 positive glioblastomas, Soroceanu et al. (2007); 29/50 primary and secondary glioblastomas, Suvasini et al. (2011)) [228,229,230,231,232]. This evidence concerns the gene IGF2 and glioblastoma.