Perhaps more importantly, it has been shown to modulate antitumor immunity, upregulating genes such as the nuclear factor of activated T cells 2 (NFATC2) and NFATC3 that regulate TCR signalling and T cell activation [36,38], as well as favouring the polarization of M1 macrophages instead of M2 macrophages in a preclinical glioblastoma model [39]. The gene discussed is NFATC3; the disease is glioblastoma.