Interestingly, a non-classical function of AChE has been linked to similar outcomes as those associated with cancer and neurodegeneration, where the AChE-derived C-terminal peptide acts at an allosteric site on the α7 nicotinic acetylcholine receptor (α7-nAChR) instead of ACh, thereby enhancing Ca2+ influx [139,140,141]. This evidence concerns the gene CHRNA7 and cancer.