Since SME reduces CML accumulation, RAGE expression, and their interaction, the effect of SME on the activation of the inflammatory responses, specifically through the nuclear translocation of nuclear factor kappa B (NF-κB) nuclear translocation and TNF-α and IL-1β staining intensity in the renal cortex, was evaluated. The gene discussed is NFKB1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.