In univariable regression analysis, the risk factors for unstable plaque were MCP-1 (OR = 1.03, 95% CI: 1.01–1.04, p = 0.002), total cholesterol (OR = 0.52, 95% CI: 0.31–0.85, p = 0.009), the presence of grade 2 hypertension (OR = 3.52, 95% CI: 1.35–9.20, p = 0.01), the presence of overweight/obesity (OR = 3.44, 95% CI: 1.28–9.29, p = 0.01), statin use (OR = 3.45, 95% CI: 1.28–9.26, p = 0.01), and sulfonylurea derivative use (OR = 0.22, 95% CI: 0.04–1.13, p = 0.06). Here, CCL2 is linked to obesity due to melanocortin 4 receptor deficiency.