Moreover, a genetic predisposition to elevated circulating MCP-1 has been associated with a higher risk of stroke, particularly in cases of large artery occlusion [18,19], while low plasma MCP-1 levels have been associated with a reduced risk of all-cause mortality, as well as less serious functional consequences after ischemic stroke or transient ischemic attack [20]. This evidence concerns the gene CCL2 and ischemic stroke.