This review was conducted by systematically searching the scientific literature to identify relevant studies addressing specific topics, such as “natural compounds in neurological disorders, mechanisms targeting neurodegenerative enzymes, Neurodegenerative Diseases; Enzyme Inhibition; Natural Molecules; Synthetic Molecules; Mechanisms of Action; Acetylcholinesterase; Monoamine Oxidase; Beta-Secretase; Caspases; Cyclooxygenase-2”. This evidence concerns the gene ACHE and nervous system disorder.