PGP and neoplasm: This multifunctional nanocomposite, which incorporates hyaluronic acid (HA) for active tumor targeting, zeolitic imidazolate framework-90 (ZIF-90) for drug delivery and inducing mitochondrial dysfunction, crizotinib (CRZ) as a therapeutic agent, and indocyanine green (ICG) for imaging and photodynamic therapy, operates through a mechanism that includes P-gp inhibition.