For instance, compounds such as curcumin, found in turmeric, and gallic acid, present in various fruits, have been shown to modulate critical signaling pathways, including PI3K/Akt and NF-κB, contributing to the inhibition of cancer cell proliferation, induction of apoptosis, and prevention of metastasis [10,11,12,13]. This evidence concerns the gene PIK3CA and cancer.