The identification of a heterozygous missense variant (RYR1 c.6838G>A, p.(Val2280Ile)) in a patient with CKD associated with recurrent rhabdomyolysis and a homozygous pathogenic variant in SLC2A9 in a patient with renal hypouricemia aligns with previous findings emphasizing the genetic basis of CKD subtypes. This evidence concerns the gene SLC2A9 and hypouricemia, renal.