Our findings underscored the pivotal role of state II wherein LGALS9 and AREG were found to interact with MET and EGFR expressed by cancer cells, respectively; additionally, VEGFA and VEGFB expressed by cancer cells interacted with FLT1 and NRP1 expressed in M1 macrophages, M2 macrophages, and germinal centre B cells. The gene discussed is AREG; the disease is cancer.