In this EOCRC population without a family history of CRC, we also examined a dominant hypothesis by identifying six patients presented with HVs in six distinct genes, three patients with HVs in DNA repair genes (BRCA2, POLQ, and RECQL4), and four patients with variants in genes regulating other cellular functions such as transcription (NCOA1), Golgi trafficking (TRIP11), and TERT regulation (NUTM1). Here, POLQ is linked to colorectal carcinoma.