However, among the subgroup of 32 EOCRC patients with a CRC family history, 4 additional patients carried variants in genes regulating TGF-β signaling (LTBP2), transcription (ETV1), cell–cell communication (EPHA10), steroid biosynthesis (HSD3B2), and vesicle-mediated transport (USP6), suggesting that cellular pathways other than DNA repair may also be involved in EOCRC risk. This evidence concerns the gene TGFB1 and colorectal carcinoma.