Previous studies investigating EOCRC populations at age cut-offs ranging from 40 to 55 years, either with small gene panels on larger populations [9,10,11], or by exome analysis on smaller populations [13,14,15,16,17,19], identified variants predominantly in DNA repair genes [9,10,11,12,16] and in putative novel cancer genes such as EIF2AK4, PTPN12, and LRP6 [14,15]. This evidence concerns the gene PTPN12 and cancer.