We identified HVs that were significantly over-represented in our EOCRC cohort compared to the GnomAD non-cancer NFE population, in the following 15 genes: BRCA2, POLQ, RAD50, RAD51C, RECQL4, CHEK2, FANCF, EPHA10, ETV1, HSD3B2, LTBP2, NCOA1, NUTM1, TRIP11, and USP6. This evidence concerns the gene CHEK2 and cancer.