To conclude, our study identifies distinct germline patterns of variants in 10 genes depending on the EOCRC patient family history with (RAD50, RAD51C, RECQL4, EPHA10, ETV1, LTPB2, USP6 genes) or without (NCOA1, NUTM1, TRIP11 genes) family history of CRC, absent in a population with a later CRC diagnosis (LOCRC). This evidence concerns the gene RAD50 and colorectal carcinoma.