Whilst two EOCRC patients carried the same HV in the RECQL4 gene (one with and the other without a CRC family history) and two other EOCRC patients (both with a CRC family history) presented with the same HV in the NUTM1 genes, none of the LOCRC patients had HVs in either of these genes. This evidence concerns the gene NUTM1 and colorectal carcinoma.