Among the HERC2 variants (rs916977–intron 12, rs7170852–intron 56, and rs12913832–intron 86), only rs7170852 was associated with melanoma risk according to the homozygous dominant and recessive models (OR = 12.22, CI = 1.48–100.91, p < 0.0001; OR = 21.92, CI = 2.73–176.14, p < 0.0001, respectively). This evidence concerns the gene HERC2 and melanoma.