For example, a GWAS meta-analysis by Landi et al., which included 36,760 melanoma cases and 375,188 controls, identified 85 significant melanoma susceptibility loci and 68 independent SNPs across several genes, including TERT, AGR3, CDKN2A, OCA2, MC1R, TP53, SLC45A2, IRF4, CCND1, GPRC5A, and FTO [41]. This evidence concerns the gene TP53 and melanoma.