The aging process can also impact the secretion of nearly all myokines, including insulin-like growth factor 1 (IGF-1), IL-5, L-β-aminoisobutyric acid (BAIBA), apelin, secreted proteins acidic and rich in cysteine (SPARCs), irisin, sesterin, and decorin, while the levels of myostatin secretion increase, leading to a direct inhibitory effect on muscle growth, which is closely related to sarcopenia. The gene discussed is IGF1; the disease is sarcopenia.