MID1IP1, a further oncogene implicated in the regulation of c-Myc, has been identified as a negative regulator of AMP-activated protein kinase (AMPK), and recent research has revealed that a depletion of MID1IP1 leads to the inhibition of c-Myc in colorectal and liver cancer growth [14], and that the inhibition of CNOT2 induces apoptosis via MID1IP1 [17]. This evidence concerns the gene MYC and liver cancer.