AKT1 and cancer: Complementary Reactome pathway (Table S7, Figure S7) analysis further supported these findings by identifying pathways with high enrichment ratios related to triglyceride catabolism, activation of matrix metalloproteinases, triglyceride metabolism, constitutive signaling by aberrant PI3K in cancer (Figure S6), and PI3K/AKT signaling in cancer pathways (Figure S7).