Despite being a putative tumor suppressor, whole exome sequencing identified a majority of heterozygous variants that consisted of 21 frameshift, 11 nonsense, 7 missense, 3 in-frame variants and 3 splice site variants spread across the coding exons of ARID1A, thus confirming other studies that have shown that a majority of ARID1A variants are frameshift and nonsense mutations [22,23,24,25]. This evidence concerns the gene ARID1A and neoplasm.