The downregulation of the biological clock gene BMAL1/CLOCK leads to circadian rhythm disruption and significant elevation of the pro-inflammatory cytokines CCL2, Interleukin-1 Beta( IL-1β), and IL-6 at the site of myocardial infarction in mice fed a high-fat diet, triggering cardiac inflammation [76]. This evidence concerns the gene IL1B and myocardial infarction.