In addition, restoration of BMAL1 circadian rhythm under pharmacological intervention attenuates cardiac fibrosis in myocardial infarction mice by restraining the AKT Serine/Threonine Kinase (AKT) signaling pathway and attenuating cardiac fibroblast (CF) proliferation and collagen production [46]. The gene discussed is AKT1; the disease is myocardial infarction.