In addition, in cardiomyocyte-specific BMAL1 knockout mice, cardiomyocyte growth and metabolism are affected due to increased cardiac sensitivity to insulin-like growth factor 1 (IGF1) and growth hormones (GHs), resulting in cardiac remodeling, contractile dysfunction, cardiomyocyte hypertrophy, and cardiac fibrosis [45]. Here, BMAL1 is linked to fibrosis.