Similar to our findings, in a previous study, L1CAM knockdown radiosensitized neuroblastoma cells by simultaneous downregulation of proto-oncogene myelocytomatosis neuroblastoma MycN and the upregulation of tumor suppressor PTEN, which inhibits PI3K/AKT/mTORC1 signaling [13]. Here, PTEN is linked to neuroblastoma.