However, two years later, in 1288 participants from the Mexico City Diabetes Study, the same group found a higher frequency of the c.2238C NPPA allele in hypertensive patients compared with normotensive individuals but no significant differences in the distribution of NPPA:rs5065 genotypes or alleles between patients with T2DM and subjects with normal glucose tolerance [40]. This evidence concerns the gene NPPA and type 2 diabetes mellitus.