NPPA and coronary artery disorder: By contrast, Wu et al. [46], in a group of 747 consecutive Southern Han Chinese patients with CAD, found no significant differences in the frequency distributions of NPPA:rs5065 genotypes or alleles between individuals with a reduced LVEF (201 patients with an LVEF of ≤45%) and those with a preserved LVEF (546 patients with an LVEF of >45%).