Therefore, the aim of our study was to analyze the associations of NPPA:rs5065 and NPPB:rs198389 polymorphisms in Polish patients with HF with the risk of HF, as well as with cardiovascular phenotypes, including type 2 diabetes mellitus (T2DM), hypertension, left ventricular mass (LVM), and LVEF. The gene discussed is NPPA; the disease is type 2 diabetes mellitus.