On the other hand, Nannipieri et al. [13] found in a homogeneous cohort of normotensive patients with type 1 diabetes that plasma ANP levels in wild-type NPPA:rs5065 homozygous subjects (TT homozygotes) were significantly higher than those in c.2238T>C heterozygotes. Here, NPPA is linked to type 1 diabetes mellitus.