The results of a meta-analysis based on 49,279 Europeans, including 10,239 subjects from the earlier meta-analysis by Meirhaeghe et al. clearly confirmed a decreased risk of T2DM in individuals homozygous for the minor allele (c.-381C) of the NPPB:rs198389 polymorphism [19]. The gene discussed is NPPB; the disease is type 2 diabetes mellitus.