NPPA and myocardial infarction: Despite no clear evidence for the association of NPPA:rs5065 with this intermediate phenotype, the results of a recent meta-analysis based on 12 studies involving more than 45,500 patients from different ethnic groups suggest that the c.2238T>C NPPA transition increases the risk of myocardial infarction, cerebrovascular events, and composite cardio-cerebral vascular events [16].