The Janus kinase (JAK)–signal transducer and activator of transcription (STAT) signaling pathway plays an essential role in the dysregulation of immune response in AD, including exaggeration of Th2 cell responses, eosinophils activation, and modulation of the epidermal barrier and peripheral nerves involved in itch, through mainly Th2 cytokine–receptor binding and phosphorylation/activation of JAK/STAT proteins [6]. This evidence concerns the gene SOAT1 and Alzheimer disease.