In rat basophilic leukemia cells, the murine macrophage cell line RAW264.7, and HaCaT keratinocytes, apigenin ameliorates allergic and inflammatory responses by inhibiting the production of cytokines (IL-6, TNF-α, and cyclooxygenase-2) and inducing skin barrier molecules (loricrin, filaggrin, and hyaluronic acid synthase) [34]. The gene discussed is TNF; the disease is acute basophilic leukemia.