VEGFA and colorectal carcinoma: TAMs, in cooperation with Tregs, transform the TME into an anti-inflammatory state by secreting chemokines such as CC Motif Chemokine Ligand 2 (CCL2), CC Motif Chemokine Ligand 5 (CCL5), VEGF, and Transforming growth factor beta (TGF-β), thereby promoting the growth and progression of advanced CRC [95].