SOST and aortic aneurysm: Consistent with the clinical results of significantly lower sclerostin levels within the human aortic aneurysm samples than those within normal human abdominal aortas [8], the sclerostin protein levels within the suprarenal aorta samples from ApoE−/− mice that developed aortic aneurysm (AA) were significantly lower than those from mice that did not develop AA after angiotensin II (AngII) infusion [8].