A recently published study proved a causal relationship between reduced sclerostin (SOST variants: rs7220711 and rs66838809) and an increased risk of coronary artery disease (OR = 1.85 [1.12, 3.06]) and type 2 diabetes (OR = 1.35 [0.98, 1.87] by Mendelian randomization (MR) analysis [31]. Here, SOST is linked to coronary artery disorder.