SAA is chronically elevated, although at more modest levels, in individuals with chronic inflammatory conditions such as rheumatoid arthritis [57,67], atherosclerosis [68,69,70], abdominal aortic aneurysms [71,72], cancer metastasis [73,74], Crohn’s disease [75] and type 2 diabetes [76]. This evidence concerns the gene SAA2 and Crohn disease.