HK2 and cancer: Similar patterns have been observed in a recent study by Kim et al. [31] where, in lung adenocarcinoma (ADC) tissues from patients, cancer cell glycolysis was associated with increased hexokinase-2 (HK2) gene expression that promoted an immunosuppressive and pro-tumorigenic state, downregulating CD8+ T-cell infiltration and increasing regulatory T-cell (Treg) infiltration.