Thermal ablation reduced the expression levels of pro-tumor-associated proteins (angiopoietin 1, ANGPT1, tyrosine kinase, and TIE2) and metabolic pathways by promoting a decreased ratio of metabolites (fatty acids, palmitic acid, and eicosapentaenoic acid) and steroid-related metabolites (corticosterone, cortisone, and cortisol) that participate in tumor angiogenesis and inflammatory responses. Here, ANGPT1 is linked to neoplasm.