Malignant gastrointestinal neuroectodermal tumor (MGNET) and clear cell sarcoma (CCS) are rare soft tissue neoplasms that, despite sharing molecular features such as EWSR1 gene rearrangements (EWSR1-CREB1 in MGNET and EWSR1-ATF1 in CCS), represent distinct pathological entities. This evidence concerns the gene EWSR1 and clear cell sarcoma.