FF with increased S6K1-mediated EZH2-induced H3K27me3-mediated WNT suppression might thus overstimulate MSCs to enter ASC commitment, paving the way to obesity, whereas BF apparently controls the appropriate postnatal magnitude of Wnt signaling in the ASC vascular niches. Here, RPS6KB1 is linked to obesity due to melanocortin 4 receptor deficiency.