Furthermore, the EZH2 inhibitor GSK126 inhibits the differentiation of MEFs into white adipocytes but promotes their differentiation into brown/beige adipocytes [256] and alleviates the obesity phenotype by promoting the differentiation of thermogenic beige adipocytes in diet-induced obese mice [648]. The gene discussed is EZH2; the disease is obesity due to melanocortin 4 receptor deficiency.