Several polymorphisms in NOS3, including Glu298Asp (rs1799983), 4 b/a (VNTR in intron 4), and –786 T>C (rs2070744), have been associated with pathologies related to endothelial dysfunction, such as essential hypertension, hypertensive disorder of pregnancy (preeclampsia), pulmonary hypertension, and multiple sclerosis, among others [39,40,41,42,43]. This evidence concerns the gene NOS3 and endothelial dysfunction.