In addition, SDF-1 plays an important role in neurogenesis [13], has proinflammatory effects on the vascular endothelium [14], intervenes in the occurrence and progression of atherosclerosis, in neurogenesis, neuro-inflammation, and interacts with other neuromodulators [15], thus explaining its implication in the pathogenesis of cerebrovascular disease in patients with type 2 DM. Here, CXCL12 is linked to atherosclerosis.