On the other hand, various authors have demonstrated beneficial effects of GLP-1 RAs on skeletal muscle, both in preclinical and clinical studies, showing that GLP-1 RA treatment inhibits muscle atrophy and promotes muscle protein synthesis [60,61], helps maintain muscle mass [62,63,64,65], or even increases it in patients with T2DM [66]. The gene discussed is GLP1R; the disease is type 2 diabetes mellitus.