The median values of defensin-5 for each of the four groups were as follows: the MASLD group (567.15 pg/mL, IQR 15.3–798.3 pg/mL), the obesity group (485.7 pg/mL, IQR 25.6–798.3 pg/mL), the control group (601.8 pg/mL, IQR 344.8–814.3 pg/mL), and the mixed group, where patients with MASLD and obesity were combined (643.8 pg/mL, IQR 485.7–798.3 pg/mL). This evidence concerns the gene DEFA5 and obesity due to melanocortin 4 receptor deficiency.