In a subpopulation of MADIT-CRT, patients with lower baseline sST2 showed a lower risk of ventricular arrhythmias and death than those with higher levels, even when adjusting for baseline BNP, and every 10% increase in sST2 values at 1 year, there was an increased risk of death or VA. This evidence concerns the gene NPPB and Ventricular arrhythmia.