TF and inflammatory bowel disease: In a murine model of inflammatory bowel disease, colitogenic CD4+ T cells expressing TF promote rapid plasma thrombin generation, resulting in a shortened clotting lag time and an increased peak thrombin level; interestingly, this TF-driven hypercoagulability can be attenuated by inhibiting disulfide isomerase—a cofactor of TF—with the flavonoid rutin [35].