NETs contribute to thrombosis through multiple mechanisms, including (i) platelet activation and aggregation: NETs provide a scaffold that enhances platelet adhesion and activation, promoting clot formation; (ii) TF expression: NET-associated proteins can upregulate TF, a key initiator of the coagulation cascade; (iii) endothelial damage: NETs induce endothelial dysfunction, exposing procoagulant surfaces that facilitate clotting; (iv) impaired fibrinolysis: NETs protect thrombi from degradation by inhibiting fibrinolysis, thereby promoting clot persistence [118]. This evidence concerns the gene TF and endothelial dysfunction.