Cyclin D1, which drives the G1 to S phase transition by complexing with CDKs 4 and 6, is commonly overexpressed in LSCC and correlates with lymph node metastasis and poorer survival; its overexpression may also occur alongside TP53 mutations [131,139,140]. Here, CCND1 is linked to metastatic malignant neoplasm in the lymph nodes.