Among these, heat shock proteins (HSPs) have diverse roles: HSP27 and HSP70 are linked to advanced tumor stage, chemoresistance (particularly to cisplatin), and radiotherapy resistance [196,197,198,199,200,201] whereas HSP47 appears to function as a tumor suppressor, with higher expression correlating with better prognosis and longer overall survival [202]. This evidence concerns the gene SERPINH1 and neoplasm.