Indeed, in aPL-positive systemic lupus erythematosus (SLE) patients, kidney biopsies are significantly delayed compared to aPL-negative patients (134.4 ± 60.6 vs. 42.6 ± 60.1 months from SLE diagnosis without differences between aPL-positive SLE patients with or without APS criteria), risking misdiagnosis or delayed diagnosis [10,11]. This evidence concerns the gene FASLG and systemic lupus erythematosus.