The analysis of the complex interdependence between the two activation pathways in human tumors has led to demonstrating how, for example, by blocking the EGFR-dependent pathways, a marked proliferation of tumor stem cells is observed in lung cancer, which occurs precisely following the activation of pathways dependent on Notch activation [112], and simultaneously targeting these two pathways leads to a strong anti-tumor efficacy [113]. This evidence concerns the gene EGFR and neoplasm.