A very recent study identifies IL-6 as a target gene in the non-canonical Notch activation pathway in breast cancer cells; in fact, the activation of the IL-6/JAK/STAT molecular axis in breast cancer cells has been shown to be mediated by IKKα/IKKβ of the NF-κB signaling cascade [38,39]. The gene discussed is NFKB1; the disease is breast carcinoma.