GK and Other metabolic disease: The absence of FAH will also cause metabolic disorders and affect the normal growth and development of insects [43]; Glycerol-3-phosphate dehydrogenase (GPDH) and glycerol kinase (GK) isozymes are linked to the production of a high quantity of glycerol as a rapid cold hardening (RCH) factor, and glycerol as main cryoprotectant plays an important role in survival throughout the cold period in this quarantine pest studied [44]; Multiple mating of Ophraella communa can significantly increase the reproductive capacity of female insects.