Secalonic acid D suppresses tumor cell survival by targeting the Akt/mTOR/p70S6K pathway, which, in turn, affects key proangiogenesis factors, such as the hypoxia-inducible factor 1α, vascular endothelial growth factor receptors, and the matrix metalloproteinase MMP-2/MMP-9. This evidence concerns the gene MTOR and neoplasm.