The main mechanism is described that TRAIL binds to the DR4 and DR5 receptors on the surface of tumor cells, triggering receptor trimerization and interacting with the Fas-associated death domain (FADD) to form the death-inducing signaling complex (DISC), activating procaspase-8, which, in turn, activates the mitochondrial pathway, promoting the release of cytochrome C, forming the Apaf-1/caspase-9 apoptosome, activating downstream caspase family proteases, and ultimately leading to apoptosis [81]. This evidence concerns the gene TNFSF10 and neoplasm.