This study aimed to investigate the prevalence of genetic variants in the PITX2 (rs2200733, rs10033464, and rs13143308), TBX5 (rs883079), PRRX1 (rs3903239), ZFHX3 (rs2106261), and HAND2 (rs7698692) polymorphisms and to assess their correlation with susceptibility to AF in a young adult population in India. Here, PRRX1 is linked to atrial fibrillation.